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The naica® system - Multiplex Crystal Digital PCR™

Get absolute quantification of multiple genetic targets in a single run with Crystal Digital PCR™

Digital PCR (dPCR) is a powerful tool used for the precise and highly sensitive quantification of nucleic acids.

The naica® system is an easy-to-use dPCR platform that harnesses cutting-edge microfluidic technology to integrate the dPCR workflow onto a single consumable chip. The technology, known as Crystal Digital PCR™, partitions samples into a large array of thousands of individual droplet crystals – each its own reaction compartment – before amplifying nucleic acid molecules in each droplet crystal. These reactions are tagged with fluorophores to be read using up to six different fluorescence light channels.

This makes for a fast and simple workflow that provides high multiplexing capability with powerful sensitivity while reducing time to results and saving precious sample.

The naica® system for Crystal Digital PCR™.

The highest multiplexing capability for digital PCR

Up to six fluorescent channels

The accurate and precise quantification of multiple targets in a single reaction saves you both time and precious sample. The naica® system provides the technology to read up to six fluorescent signatures in one well, providing unmatched multiplexing power and flexibility in complex assay design.

The naica® system is available in two configurations, with 3-color or 6-color detection channel read out.

Software results you can see

Get answers instead of data

Crystal Miner software provides intuitive visuals for image analysis, allowing thorough exploration of Droplet Crystals for quality control. Crystal Miner software measures the concentrations of targeted nucleic acids, providing automatic identification of positive and negative droplets for all fluorescence channels.

Along with the ability to read data arranged along 1D, 2D, and 3D dot plots, the naica® system software will give access to raw data to export all experiment details and results.

Range of applications

Greater precision, accuracy, and sensitivity through digital PCR

Increasing adaptability across application areas

Digital PCR has proven its adaptability in numerous molecular assays and is now recognized as a reliable method not only for rare alleles and rare mutations detection but also for genotyping, absolute quantification, and copy number variation.

The naica® system has been successfully implemented in the wide variety of applications, including:

  • Cancer and liquid biopsy
  • Cell and gene therapy
  • Infection disease detection
  • GMO and environmental testing
lab tools

Easy-to-use dPCR

High performance. Low complexity.

With a combination of high multiplexing assay design compatibility, powerful imaging, the flexibility to use up to six detection channels, and proprietary software for analysis, the naica® system brings simplicity to any digital PCR application.

Little technical expertise is required to operate the platform – with ready-to-use optimized digital PCR reagents and simple pipetting steps, chip consumables are ready for partitioning, amplification, and read-out. Assays can be run with just a few minutes of actual hands-on time needed.

The naica® system is comprised of:

  • Ready-to-use naica® system PCR MIX reagents and pre-design multiplex assay kits
  • Consumable chips (Sapphire or Ruby)
  • Geode (automated droplet generator and thermocycler)
  • Prism3 or Prism6 (multi-color fluorescence imager)
  • Crystal Reader and Crystal Miner software (experimental parameter set-up and data analysis)

For Research Use Only. Not for use in diagnostic procedures.

Learn More

To learn more about the the naica® system and applications for digital PCR, visitor our Digital PCR Learning Center.